Why humans age and how to reverse or at least minimize aging?

The practical guide to health & longevity

This article is based on my research of information from publicly available sources and my personal experience. The information, opinions, and references provided in this article are for informational purposes only. This article is not a medical advise and is not intended to treat, diagnose or prescribe for any illness or condition. Please consult your doctor or healthcare provider for your specific diagnosis and treatment.

This is the 2nd article in the Longevity Principle series. In part 1, we discussed how long we are likely to live and how to increase a chance of living to 100+ and possibly to 200. We concluded that we want to be in the dark green “strong health” quadrant — it would increase a chance of living to 100+ years from 2% to 5%.

Here in part 2, we will cover:
— Why humans age?
— How to reverse or at least minimize aging?
— The 8 longevity principles to stop aging

The authors define the aging hallmark as follows:

Unfortunately, these hallmarks of aging are not actionable for normal people. My intention is to translate them into actionable recommendations.

A more actionable way to look at this is from the aging-related disease standpoint. Let’s look at the global deaths statistics — two thirds of people die from the aging-related diseases such as cancer, cardiovascular diseases, and diabetes. Interestingly, animals rarely have these diseases because they normally have healthier lifestyles.

If you study scientific literature on longevity, you will find that there are 10–15 key pathways associated with health and longevity. To live longer, you need to upregulate, downregulate or maintain them in balance.

Since we started to use some technical terms, I’ll take a second to introduce them:

Also, I use a broad definition of longevity pathways which includes molecular level (e.g., mTOR activity), cellular/tissue level (e.g., autophagy), and systemic/organism level pathways (e.g., inflammation). The reason is simple — longevity, i.e., extending your lifespan, is not possible without keeping good health. Here are 2 examples of why it is important:

It’s important to note that:

There are many practitioners and scientists who have great research on longevity and health: Dave Asprey (the BulletProof inventor and an inventor of the term “biohacking”), Steven R Gundry MD(a former cardiac surgeon who now specializes on nutritional medicine), Satchin Panda (the leading expert in the field of circadian rhythm research), Peter Attia MD (a former cancer surgeon who now specializes on the applied longevity), Rhonda Patrick (the founder of FoundMyFitness), and many others. They inspired me to start my longevity quest.

My research led me to believe that everything you can do to live longer aims to reach one or more of the 4 objectives:

Each longevity objective can be achieved by following the 8 longevity principles. Let’s take a closer look at them.

Our bodies constantly accumulate toxins acquired from exogenous (food, water, and environment) and endogenous sources (cellular and metabolic waste from our blood and organs) which damage our genes and cells and disrupt biological processes. Toxin removal leverages multiple organs: liver, kidneys, lymph, colon, lungs, and skin.

The human genome is ”the collective library” of genes. The human epigenome is ”the recipe book” from “the collective library” used to build different types of cells.

In my research, I dug deeper into each principle breaking it down the “What”, the “Why”, and the “How”:

Stay tuned to learn more.

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